Current status of vaccines for schistosomiasis

DP McManus, A Loukas - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized
as the most important human helminth infection in terms of morbidity and mortality. Infection …

Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam

DP McManus, DJ Gray, Y Li, Z Feng… - Clinical microbiology …, 2010 - Am Soc Microbiol
The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in
China has invoked considerable global concern. The TGD will result in changes in the water …

Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis

MH Tran, MS Pearson, JM Bethony, DJ Smyth… - Nature medicine, 2006 - nature.com
Schistosomes are blood-dwelling flukes that infect 200 million people worldwide and are
responsible for hundreds of thousands of deaths annually. Using a signal sequence trap, we …

Vaccines to combat the neglected tropical diseases

JM Bethony, RN Cole, X Guo, S Kamhawi… - Immunological …, 2011 - Wiley Online Library
The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious
diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm …

Proteomic analysis of Schistosoma mansoni cercarial secretions

GM Knudsen, KF Medzihradszky, KC Lim… - Molecular & Cellular …, 2005 - ASBMB
Schistosomiasis is a global health problem caused by several species of schistosome blood
flukes. The initial stage of infection is invasion of human skin by a multicellular larva, the …

Invertebrate muscles: muscle specific genes and proteins

SL Hooper, JB Thuma - Physiological reviews, 2005 - journals.physiology.org
This is the first of a projected series of canonic reviews covering all invertebrate muscle
literature prior to 2005 and covers muscle genes and proteins except those involved in …

Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults

M Santini-Oliveira, RN Coler, J Parra, V Veloso… - Vaccine, 2016 - Elsevier
Abstract Design Safety and immunogenicity of a recombinant 14 kDa, fatty acid-binding
protein (FABP) from Schistosoma mansoni (rSm14) were evaluated through an open, non …

Schistosome membrane proteins as vaccines

A Loukas, M Tran, MS Pearson - International journal for parasitology, 2007 - Elsevier
Schistosomes are parasitic blood flukes that infect approximately 200 million people and are
arguably the most important human helminth in terms of mortality. The outermost surface of …

Schistosomes: the road from host–parasite interactions to vaccines in clinical trials

A Capron, G Riveau, M Capron, F Trottein - Trends in Parasitology, 2005 - cell.com
Insights over recent years into the interactions between helminths, including schistosomes,
and the immune system have generated new concepts in immunology and significant …

Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach?

NR Bergquist, LR Leonardo, GF Mitchell - Trends in parasitology, 2005 - cell.com
The present strong emphasis on gross organ pathology (liver, kidneys, bladder) in
schistosomiasis needs to be replaced with a more balanced view of the disease that also …