This second article in the series on pragmatic trials describes the challenges in selection of
sites for pragmatic clinical trials and the impact on validity, precision, and generalizability of …

The relationship between community prevalence of Plasmodium falciparum and the burden
of severe, life-threatening disease remains poorly defined. To examine the three most …

Many interventions are not disruptive enough of the patterns that entrench poor health and
health inequities. Ways forward may require a break with tradition to embrace system …

Objectives The overuse of antimalarial drugs is widespread. Effective methods to improve
prescribing practice remain unclear. We evaluated the impact of 10 interventions that …

The safety and efficacy of the two most widely used fixed-dose artemisinin-based
combination therapies (ACT), artesunate-amodiaquine (ASAQ) and artemether-lumefantrine …

Health systems in many African countries are failing to provide populations with access to
good quality health care. Morbidity and mortality from curable diseases such as malaria …

The ways in which dimensions of health and healthcare intersect with economics and
politics in particular contexts requires close attention. In this article we connect concerns …

Background Despite significant investments into health improvement programmes in
Uganda, health indicators and access to healthcare remain poor across the country. The …

Background Rapid diagnostic tests for malaria (mRDTs) have been scaled-up widely across
Africa. The PRIME study evaluated an intervention aiming to improve fever case …

We explored associations between Plasmodium falciparum drug resistance–mediating
polymorphisms and clinical presentations in parasitemic children enrolled in a cross …