Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

[HTML][HTML] Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

LF Dong, J Rohlena, R Zobalova, Z Nahacka… - Journal of Cell …, 2023 - rupress.org
Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Mitophagy in diabetic cardiomyopathy: roles and mechanisms

H Zheng, H Zhu, X Liu, X Huang, A Huang… - Frontiers in Cell and …, 2021 - frontiersin.org
Cardiovascular disease is the leading complication of diabetes mellitus (DM), and diabetic
cardiomyopathy (DCM) is a major cause of mortality in diabetic patients. Multiple …

The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics

A Li, L Lian, X Chen, W Cai, X Fan, Y Fan, T Li… - Free Radical Biology …, 2023 - Elsevier
Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Challenges in promoting mitochondrial transplantation therapy

Y Yamada, M Ito, M Arai, M Hibino, T Tsujioka… - International Journal of …, 2020 - mdpi.com
Mitochondrial transplantation therapy is an innovative strategy for the treatment of
mitochondrial dysfunction. The approach has been reported to be useful in the treatment of …

Mitochondrial transplantation by intra-arterial injection for acute kidney injury

IP Doulamis, A Guariento, T Duignan… - American Journal …, 2020 - journals.physiology.org
Acute kidney injury is a common clinical disorder and one of the major causes of morbidity
and mortality in the postoperative period. In this study, the safety and efficacy of autologous …

Mitochondria transfer and transplantation in human health and diseases

ZH Wang, L Chen, W Li, L Chen, YP Wang - Mitochondrion, 2022 - Elsevier
Mitochondria are dynamic organelles responsible for energy production and cell
metabolism. Disorders in mitochondrial function impair tissue integrity and have been …

Mitochondrial transplantation for organ rescue

JD McCully, PJ Del Nido, SM Emani - Mitochondrion, 2022 - Elsevier
Mitochondrial transplantation involves the replacement or augmentation of native
mitochondria damaged, by ischemia, with viable, respiration-competent mitochondria …

Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease

Y Chen, F Yang, Y Chu, Z Yun, Y Yan, J Jin - Journal of Translational …, 2022 - Springer
Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease
(NAFLD), are rising in both incidence and prevalence and remain a major global health and …

Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute …

Z Pourmohammadi-Bejarpasi, AM Roushandeh… - Brain Research …, 2020 - Elsevier
Acute ischemia stroke (AIS) is one of the leading causes of mortality and disability
worldwide, and its neurological impacts are devastating and permanent. There is no efficient …