Cancer is a malignant disease that has plagued human beings all the time, but the treatment
effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their …

Objective: Methotrexate (MTX) is a drug used in the treatment of cancer and autoimmune
disorders; however, its clinical use is limited because of serious side effects including renal …

Triple-negative breast cancer (TNBC) is the most aggressive and fatal subtype of breast
cancer with disappointing treatment and high mortality. Tumor microenvironment (TME) …

Methotrexate successful therapy encounters various challenges in chemotherapy, such as
poor oral bioavailability, low specificity, side effects and the development of drug …

Despite the appealing properties of random copolymers, the use of these biomaterials in
association with phospholipids is still limited, as several aspects of their performance have …

Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-
androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges …

This study aimed to investigate the potential of silver nanoparticles coated with polyvinyl
alcohol and conjugated with methotrexate (AgNPs@ PVA-MTX) as a novel therapeutic …

This short note presents the data and rationale for adding five generic non-oncology drugs
from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic …

全球恶性肿瘤发病人数和死亡人数仍呈逐年上升趋势, 严重威胁人类健康与生命,
造成巨大的疾病负担. 在人口众多, 且老龄化日益加重的中国, 这种趋势尤其严重 …

In recent years, nanomaterials have been intensively studied and applied in various fields,
including pharmaceutical applications. This platform can act as a carrier for anticancer drugs …