Objectives Despite extensive effort, the search for clinically-relevant metabolite biomarkers
for early detection, disease monitoring, and outcome prediction in lung cancer remains …

Background Immuno-oncotherapy has emerged as a promising means to target cancer. In
particular, therapeutic manipulation of tumor-associated macrophages holds promise due to …

The dynamic interactions between macrophages and T-lymphocytes in the tumor
microenvironment exert both antagonistic and synergistic functions affecting tumor growth …

The standard of care for intermediate (Stage II) and advanced (Stages III and IV) non-small
cell lung cancer (NSCLC) involves chemotherapy with taxane/platinum derivatives, with or …

The complex interactions between subclinical changes to hepatic extracellular matrix (ECM)
in response to injury and tumor-associated macrophage microenvironmental cues …

Cancer has traditionally been studied from a basic science perspective, focusing on the
underlying biology, physiology, and biochemistry. Engineering has supplemented this effort …

Identification of protein biomarkers for cancer diagnosis and prognosis remains a critical
unmet clinical need. A major reason is that the dynamic relationship between proliferating …

Biomarkers remain the highest value proposition in cancer medicine today—especially
protein biomarkers. Despite decades of evolving regulatory frameworks to facilitate the …

There are multiple levels of heterogeneity within the tumor microenvironment from molecular
heterogeneity, to heterogeneity in cellular populations. This heterogeneity is a major factor …

This article explores the overlap between systems biology and predictive neuroscience,
placing them in their larger context, the contemporary trend of bioinformatic convergence …