The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

The light responses of rod and cone photoreceptors in the vertebrate retina are
quantitatively different, yet extremely stable and reproducible because of the extraordinary …

Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary
intracellular messenger for the visual signaling pathway that converts a light stimulus into an …

Mutations in the gene encoding the catalytic subunit of the cone photoreceptor
phosphodiesterase (PDE6C) have been recently reported in patients with autosomal …

Mutations in PDE6 genes encoding the effector enzymes in rods and cones underlie severe
retinal diseases including retinitis pigmentosa (RP), autosomal dominant congenital …

Phosphodiesterase 6 (PDE6) is the effector enzyme in the phototransduction cascade and is
critical for the health of both rod and cone photoreceptors. Its dysfunction, caused by …

Phosphodiesterase-6 (PDE6) is the key effector enzyme of the phototransduction cascade in
rods and cones. The catalytic core of rod PDE6 is a unique heterodimer of PDE6A and …

Phosphodiesterase-6 (PDE6) is a multisubunit enzyme that plays a key role in the visual
transduction cascade in rod and cone photoreceptors. Each type of photoreceptor utilizes …

Rhodopsin is a G protein-coupled receptor (GPCR) that initiates the phototransduction
cascade in retinal disc membrane. Recent studies have suggested that rhodopsin forms …