Childhood cancer: survival, treatment modalities, late effects and improvements over time

F Erdmann, LE Frederiksen, A Bonaventure… - Cancer …, 2021 - Elsevier
Since the 1960s, paediatric oncologists have gradually become better organised in large
study groups and participation in clinical trials is today considered as the standard of care …

Targeting molecular mechanisms underlying treatment efficacy and resistance in osteosarcoma: a review of current and future strategies

I Lilienthal, N Herold - International journal of molecular sciences, 2020 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

J Theruvath, M Menard, BAH Smith, MH Linde… - Nature medicine, 2022 - nature.com
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal
antibodies targeting GD2 have substantially improved outcomes for children with high-risk …

Long-term care for people treated for cancer during childhood and adolescence

ES Tonorezos, RJ Cohn, AW Glaser, J Lewin, E Poon… - The Lancet, 2022 - thelancet.com
Worldwide advances in treatment and supportive care for children and adolescents with
cancer have resulted in a increasing population of survivors growing into adulthood. Yet, this …

Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century

MJ Ehrhardt, KR Krull, N Bhakta, Q Liu… - Nature Reviews …, 2023 - nature.com
The contributions of cooperative groups to performing large-cohort clinical trials and long-
term survivorship studies have facilitated advances in treatment, supportive care and …

Derivation of anthracycline and anthraquinone equivalence ratios to doxorubicin for late-onset cardiotoxicity

EAM Feijen, WM Leisenring, KL Stratton… - JAMA …, 2019 - jamanetwork.com
Importance Anthracyclines are part of many effective pediatric cancer treatment protocols.
Most pediatric oncology treatment groups assume that the hematologic toxicity of …

American Cancer Society nutrition and physical activity guideline for cancer survivors

CL Rock, CA Thomson, KR Sullivan… - CA: a cancer journal …, 2022 - Wiley Online Library
The overall 5‐year relative survival rate for all cancers combined is now 68%, and there are
over 16.9 million survivors in the United States. Evidence from laboratory and observational …

Cohort profile: the St. Jude Lifetime Cohort Study (SJLIFE) for paediatric cancer survivors

CR Howell, KL Bjornard, KK Ness… - International Journal …, 2021 - academic.oup.com
However, in the early years of these studies, many were limited by dependence upon self-
reported outcomes or registry data, smaller population sizes and restriction to single disease …

Life expectancy of adult survivors of childhood cancer over 3 decades

JM Yeh, ZJ Ward, A Chaudhry, Q Liu, Y Yasui… - JAMA …, 2020 - jamanetwork.com
Importance Advances in childhood and adolescent cancer treatment have been associated
with increased rates of cure during the past 3 decades; however, improvement in adult life …

Therapy-related cardiac risk in childhood cancer survivors: an analysis of the childhood cancer survivor study

JE Bates, RM Howell, Q Liu, Y Yasui… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE The impacts of radiotherapy dose and exposed cardiac volume, select
chemotherapeutic agents, and age at exposure on risk for late-onset cardiac disease in …