Hazardous drinking and alcohol use disorders

J MacKillop, R Agabio, SW Feldstein Ewing… - Nature Reviews …, 2022 - nature.com
Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Ultrasound‐activated sensitizers and applications

X Lin, J Song, X Chen, H Yang - … Chemie International Edition, 2020 - Wiley Online Library
Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative
depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from …

Novel agents for the pharmacological treatment of alcohol use disorder

EM Burnette, SJ Nieto, EN Grodin, LR Meredith… - Drugs, 2022 - Springer
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Alcohol-related liver disease: basic mechanisms and clinical perspectives

SY Liu, IT Tsai, YC Hsu - International journal of molecular sciences, 2021 - mdpi.com
Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …

Impact of alcohol use disorder treatment on clinical outcomes among patients with cirrhosis

S Rogal, A Youk, H Zhang, WF Gellad, MJ Fine… - Hepatology, 2020 - journals.lww.com
In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary
hemostasis, coagulation, and fibrinolysis. They involve prohemorrhagic and prothrombotic …

Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling

M Terunuma - Proceedings of the Japan Academy, Series B, 2018 - jstage.jst.go.jp
Abstract γ-aminobutyric acid type B (GABA B) receptors are broadly expressed in the
nervous system and play an important role in neuronal excitability. GABA B receptors are G …

Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

R Agabio, JMA Sinclair, G Addolorato… - The Lancet …, 2018 - thelancet.com
Alcohol use disorder is a leading cause of morbidity and mortality. 1–2 Alcohol consumption
is related to approximately 4% of the global burden of disease. 1 In clinical settings and …

State-of-the-art behavioral and pharmacological treatments for alcohol use disorder

LA Ray, S Bujarski, E Grodin, E Hartwell… - The American journal …, 2019 - Taylor & Francis
Background: Alcohol use disorder (AUD) and its associated consequences remain
significant public health concerns. Given that AUD represents a spectrum of severity …

Statin use and the risk of hepatocellular carcinoma in patients with chronic hepatitis B

MJ Goh, DH Sinn, S Kim, SY Woo, H Cho, W Kang… - Hepatology, 2020 - journals.lww.com
Conclusions Most Veterans with cirrhosis and coexisting AUD did not receive behavioral
therapy or pharmacotherapy treatment for AUD over a 6‐month follow‐up. The reductions in …

Efficacy and tolerability of baclofen in a US community population with alcohol use disorder: a dose-response, randomized, controlled trial

JC Garbutt, AB Kampov-Polevoy, C Pedersen… - …, 2021 - nature.com
Identification of new medications for alcohol use disorder (AUD) is important for improving
treatment options. Baclofen, a GABAB agonist, has been identified as a potential …