Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Recent progress in fluorescent probes for bacteria

Y Huang, W Chen, J Chung, J Yin, J Yoon - Chemical Society Reviews, 2021 - pubs.rsc.org
Food fermentation, antibiotics, and pollutant degradation are closely related to bacteria.
Bacteria play an irreplaceable role in life. However, some bacteria seriously threaten human …

Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel

N Raje, K Anderson, H Einsele, Y Efebera, F Gay… - Blood cancer …, 2023 - nature.com
Bispecific antibodies (BsAbs) are emerging as an important novel class of
immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing

N Liu, S Zhu, Y Deng, M Xie, M Zhao, T Sun, C Yu… - Bioactive Materials, 2023 - Elsevier
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected
wounds or even severe tissue damage. In this study, we developed a controlled-release …

Staphylococcal trafficking and infection—from 'nose to gut'and back

EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Embracing complexity in sepsis

AR Schuurman, PMA Sloot, WJ Wiersinga… - Critical Care, 2023 - Springer
Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of
organ systems, medical interventions and a myriad of other factors. This together results in a …

Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

AA Ordonez, H Wang, G Magombedze… - Nature medicine, 2020 - nature.com
Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at
least 6 months of multidrug treatment to achieve cure. However, the lack of reliable data on …

Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography

AA Ordonez, LM Wintaco, F Mota… - Science translational …, 2021 - science.org
Enterobacterales represent the largest group of bacterial pathogens in humans and are
responsible for severe, deep-seated infections, often resulting in sepsis or death. They are …

Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim

IK Lee, DA Jacome, JK Cho, V Tu… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Several molecular imaging strategies can identify bacterial infections in
humans. PET affords the potential for sensitive infection detection deep within the body …