• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Aims Genetic testing is recommended in specific inherited heart diseases but its role
remains unclear and it is not currently recommended in unexplained cardiac arrest (UCA) …

Background Genetic testing following sudden cardiac death (SCD) is currently guided by
autopsy findings, despite the inherent challenges of autopsy examination and mounting …

In the early nineties, few years before the birth of Europace, the clinical and scientific world
of familial arrhythmogenic conditions was revolutionized by the identification of the first …

In the forensic medicine field, molecular autopsy is the post-mortem genetic analysis
performed to attempt to unravel the cause of decease in cases remaining unexplained after …

Background: Sudden cardiac arrest (SCA) and sudden unexplained death (SUD) are feared
sequelae of many genetic heart diseases. In rare circumstances, pathogenic variants in …

Abstract ACTN2 encodes alpha‐actinin‐2, a protein expressed in human cardiac and
skeletal muscle. The protein, located in the sarcomere Z‐disk, functions as a link between …

Sudden death cases in the young population remain without a conclusive cause of decease
in almost 40% of cases. In these situations, cardiac arrhythmia of genetic origin is suspected …

A genetic risk of sudden cardiac arrest and sudden death due to an arrhythmic cause,
known as sudden cardiac death (SCD), has become apparent from epidemiological studies …