Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …

Leptin plays a central role in the control of body weight and energy homeostasis, but is a
pleiotropic cytokine with activities on many peripheral cell types. In this review, we discuss …

The specific activity of enzymes can be altered over long timescales in cells by synonymous
mutations that alter a messenger RNA molecule's sequence but not the encoded protein's …

The increasing role of topology in (bio) physical properties of matter creates a need for an
efficient method of detecting the topology of a (bio) polymer. However, the existing tools …

More than 20 years after characterization of the key regulator of mammalian energy balance,
leptin, we identified the leptin (LEP) genes of chicken (Gallus gallus) and duck (Anas …

We identify new entangled motifs in proteins that we call complex lassos. Lassos arise in
proteins with disulfide bridges (or in proteins with amide linkages), when termini of a protein …

As a multi-potency cytokine, leptin not only plays a crucial role in controlling weight and
energy homeostasis but also participates in the metabolic balance in the human body …

Discovery of the satiety hormone leptin in 1994 and its characterization in mammals
provided a key tool to deciphering the complex mechanism governing adipose tissue …

Abstract The LassoProt server, http://lassoprot. cent. uw. edu. pl/, enables analysis of
biopolymers with entangled configurations called lassos. The server offers various ways of …

Angiotensin-converting enzyme 2 (ACE2) is the host cellular receptor that locks onto the
surface spike protein of the 2002 SARS coronavirus (SARS-CoV-1) and of the novel, highly …