Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

Predictive processing is a computational framework that aims to explain how the brain
processes sensory information by making predictions about the environment and minimizing …

Aberrant dopaminergic and glutamatergic function, particularly within the striatum and
hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia …

This narrative review explores the efficacy and tolerability of third-generation antipsychotics
(TGAs)—aripiprazole, cariprazine, brexpiprazole, and lurasidone—for the management of …

Excess dopamine release in the dorsal striatum (DS) is linked to psychosis. Antipsychotics
are thought to work by blocking striatal D2 dopamine receptors, but they lack efficacy for the …

Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug discovery.
Its flexibility increases the molecule's capability to bind to the receptor. The piperidine …

The palatability and concentration of sweet foods promote hedonic feeding beyond
homeostatic need. Understanding how neurons respond to sweet taste is thus of great …

Background The ganglionic eminences (GE) are fetal-specific structures that give rise to
gamma-aminobutyric acid (GABA)-and acetylcholine-releasing neurons of the forebrain …

Robust epidemiological evidence of risk and protective factors for psychosis is essential to
inform preventive interventions. Previous evidence syntheses have classified these risk and …