Natural compounds, in recent years, have attracted significant attention for their use in the
prevention and treatment of diverse chronic diseases as they are devoid of major toxicities …

Telomeres, the protective structures of chromosome ends are gradually shortened by each
cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the …

The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …

Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including
the red clover (Trifolium pratense) and Chinese medicinal plant Astragalus membranaceus …

Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic
potential may have a high telomerase activity, allowing cells to escape from the inhibition of …

The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation
and senescence of normal somatic cells as well as cancer cells. This complex is comprised …

Modern phytotherapy is part of today's conventional evidence-based medicine and the use
of phytopharmaceuticals in integrative oncology is becoming increasingly popular …

Purpose The acquisition of pathogenic variants in the TERT promoter (TERTp) region is a
mechanism of tumorigenesis. In nonmalignant diseases, TERTp variants have been …