Compounds containing 1, 3, 4-oxadiazole ring in their structure are characterised by
multidirectional biological activity. Their anti-proliferative effects associated with various …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …

The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …

Abstract New series of benzothiazole-1, 2, 3-triazoles; appended with benzothiazole, isatin
and/or benzimidazole moiety; were designed and synthesized through the click chemistry …

Abstract A new series of 1, 3, 4-oxadiazole/chalcone hybrids was designed, synthesized,
identified with different spectroscopic techniques and biologically evaluated as inhibitors of …

Novel antibiotics are forced to be developed on account of multidrug-resistant bacteria with
serious threats to human health. This work developed isatin-derived azoles as new potential …

Thymidine phosphorylase (TP) is over expressed in several solid tumors and its inhibition
can offer unique target suitable for drug discovery in cancer. A series of 1, 2, 4-triazoles 3a …

In the current study, five isatin hydrazone schiff base linked acetylinic scaffolds have been
synthesized via condensation reaction of isatin hydrazone with aldehydic groups. In order to …

Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …