Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis
H Shinoda, T Iida, A Makino, M Yoshimura… - Communications …, 2022 - nature.com
In the ongoing COVID-19 pandemic, rapid and sensitive diagnosis of viral infection is a
critical deterrent to the spread of SARS-CoV-2. To this end, we developed an automated …
critical deterrent to the spread of SARS-CoV-2. To this end, we developed an automated …
Detection and discrimination of single nucleotide polymorphisms by quantification of CRISPR-Cas catalytic efficiency
The specificity of CRISPR-Cas12 assays is attractive for the detection of single nucleotide
polymorphisms (SNPs) implicated in, eg, cancer and SARS-CoV-2 variants. Such assays …
polymorphisms (SNPs) implicated in, eg, cancer and SARS-CoV-2 variants. Such assays …
Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA
O Dmytrenko, GC Neumann, T Hallmark, DJ Keiser… - bioRxiv, 2022 - biorxiv.org
Bacterial abortive infection systems limit the spread of foreign invaders by shutting down or
killing infected cells before the invaders can replicate,. Several RNA-targeting CRISPR-Cas …
killing infected cells before the invaders can replicate,. Several RNA-targeting CRISPR-Cas …