Designing biological circuits: from principles to applications

D Chakraborty, R Rengaswamy… - ACS Synthetic Biology, 2022 - ACS Publications
Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first
genetic circuits─ the repressilator and the toggle switch─ were designed and implemented …

How retroactivity affects the behavior of incoherent feedforward loops

J Wang, C Belta, SA Isaacson - Iscience, 2020 - cell.com
An incoherent feedforward loop (IFFL) is a network motif known for its ability to accelerate
responses and generate pulses. It remains an open question to understand the behavior of …

DOSE-L1000: unveiling the intricate landscape of compound-induced transcriptional changes

J Wang, S Novick - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation The LINCS L1000 project has collected gene expression profiles for
thousands of compounds across a wide array of concentrations, cell lines, and time points …

Dynamical Effects of the Load on Self-sustained Oscillators

X Ju, H Wang - Beijing Da Xue Xue Bao, 2023 - search.proquest.com
The effect of loads on self-sustained oscillators was studied by using numerical simulations
and theoretical analysis with simple biological and chemical oscillators. Analyses of …