Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Frame-disrupting mutations in the DMD gene, encoding dystrophin, compromise myofiber
integrity and drive muscle deterioration in Duchenne muscular dystrophy (DMD). Removing …

Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite
cells)(MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis …

The elderly often suffer from progressive muscle weakness and regenerative failure. We
demonstrate that muscle regeneration is impaired with aging owing in part to a cell …

Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

The prospective isolation of purified stem cell populations has dramatically altered the field
of stem cell biology, and it has been a major focus of research across tissues in different …

Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit
robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered …

Diminished regenerative capacity of skeletal muscle occurs during adulthood. We identified
a reduction in the intrinsic capacity of mouse adult satellite cells to contribute to muscle …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …