A comprehensive review on structural and therapeutical insight of Cerebroside sulfotransferase (CST)-An important target for development of substrate reduction …

N Singh, AK Singh - International Journal of Biological Macromolecules, 2024 - Elsevier
This review is an effort towards the development of substrate reduction therapy using
cerebroside sulfotransferase (CST) as a target protein for the development of inhibitors …

Overview and limitations of database in global traditional medicines: A narrative review

X Li, J Zhang, X Shen, Y Zhang, D Guo - Acta Pharmacologica Sinica, 2024 - nature.com
The study of traditional medicine has garnered significant interest, resulting in various
research areas including chemical composition analysis, pharmacological research, clinical …

Modern drug discovery using ethnobotany: a large-scale cross-cultural analysis of traditional medicine reveals common therapeutic uses

D Domingo-Fernández, Y Gadiya, S Mubeen… - Iscience, 2023 - cell.com
For millennia, numerous cultures and civilizations have relied on traditional remedies
derived from plants to treat a wide range of conditions and ailments. Here, we systematically …

Chemical Multiverse and Diversity of Food Chemicals

JF Avellaneda-Tamayo… - Journal of Chemical …, 2024 - ACS Publications
Food chemicals have a fundamental role in our lives, with an extended impact on nutrition,
disease prevention, and marked economic implications in the food industry. The number of …

HTINet2: herb–target prediction via knowledge graph embedding and residual-like graph neural network

P Duan, K Yang, X Su, S Fan, X Dong… - Briefings in …, 2024 - academic.oup.com
Target identification is one of the crucial tasks in drug research and development, as it aids
in uncovering the action mechanism of herbs/drugs and discovering new therapeutic targets …

Molecular Dynamics Simulation and Pharmacoinformatic Integrated Analysis of Bioactive Phytochemicals from Azadirachta indica (Neem) to Treat Diabetes Mellitus

A Abdullah, P Biswas, M Sahabuddin… - Journal of …, 2023 - Wiley Online Library
Diabetes mellitus is a chronic hormonal and metabolic disorder in which our body cannot
generate necessary insulin or does not act in response to it, accordingly, ensuing in …

Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model

KS Yadav, AC Bisen, S Ishteyaque… - Journal of Ocular …, 2024 - liebertpub.com
Purpose: Glaucoma is a complex degenerative optic neuropathy characterized by loss of
retinal ganglion cells (RGCs) leading to irreversible vision loss and blindness. Solanum …

[HTML][HTML] Discovery of multitarget-directed small molecule inhibitors from Andrographis paniculata for Nipah virus disease therapy: Molecular docking, molecular …

M Mandal, S Mandal - Chemical Physics Impact, 2024 - Elsevier
Nipah virus (NiV), an emerging highly infectious agent, causes fatal infection to humans
through zoonosis, particularly in Asian countries including India. No specific treatment or …

Exploration of selected monoterpenes as potential TRPC channel family modulator in lung cancer, an in-silico upshot

A Singh, A Mishra, A Meena, N Mishra… - Journal of Biomolecular …, 2024 - Taylor & Francis
Lung cancer is still the most frequent cause of cancer-related death, accounting for nearly
two million cases yearly. As cancer is a multifactorial disease, developing novel molecular …

Targeting Filamenting temperature-sensitive mutant Z (FtsZ) with bioactive phytoconstituents: An emerging strategy for antibacterial therapy

BS Alotaibi - Plos one, 2023 - journals.plos.org
The rise and widespread occurrence of bacterial resistance has created an evident need for
novel antibacterial drugs. Filamenting temperature-sensitive mutant Z (FtsZ) is a crucial …