Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …

A long-standing association exists between elevated triglyceride levels and cardiovascular
disease*(CVD). 1, 2 However, the extent to which triglycerides directly promote CVD or …

Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic
abnormalities. With time, multiple glucose-lowering medications are commonly required to …

Background: As newer oral diabetes agents continue to emerge on the market, comparative
evidence is urgently required to guide appropriate therapy. Purpose: To summarize the …

Since the first discovery of an inverse correlation between high‐density lipoprotein‐
cholesterol (HDL‐C) levels and coronary heart disease in the 1950s the life cycle of HDL, its …

Increased plasma levels of triglycerides (TG) in very low density lipoproteins (VLDL) are not
only common characteristics of the dyslipidemia associated with insulin resistance and type …

The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α
and PPAR-δ, are nuclear receptors that have been the focus of extensive research during …

OBJECTIVE—Published reports suggest that pioglitazone and rosiglitazone have different
effects on lipids in patients with type 2 diabetes. However, these previous studies were …