Pulmonary hypertension

A Mocumbi, M Humbert, A Saxena, ZC Jing… - Nature Reviews …, 2024 - nature.com
Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …

Pulmonary arterial hypertension: pathogenesis and clinical management

T Thenappan, ML Ormiston, JJ Ryan, SL Archer - Bmj, 2018 - bmj.com
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

Epidemiology and treatment of pulmonary arterial hypertension

EMT Lau, E Giannoulatou, DS Celermajer… - Nature Reviews …, 2017 - nature.com
In the past 2 decades, major changes have occurred in the epidemiological and treatment
landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of …

Cell death in the lung: the apoptosis–necroptosis axis

M Sauler, IS Bazan, PJ Lee - Annual review of physiology, 2019 - annualreviews.org
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Relevant issues in the pathology and pathobiology of pulmonary hypertension

RM Tuder, SL Archer, P Dorfmüller, SC Erzurum… - Journal of the American …, 2013 - jacc.org
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

Pulmonary arterial hypertension: the clinical syndrome

YC Lai, KC Potoka, HC Champion, AL Mora… - Circulation …, 2014 - Am Heart Assoc
Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction
and vascular remodeling obstruct small pulmonary arteries, resulting in increased …

[HTML][HTML] Mechanisms of disease: pulmonary arterial hypertension

RT Schermuly, HA Ghofrani, MR Wilkins… - Nature Reviews …, 2011 - nature.com
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

The latest in animal models of pulmonary hypertension and right ventricular failure

O Boucherat, V Agrawal, A Lawrie, S Bonnet - Circulation research, 2022 - Am Heart Assoc
Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Current and future treatments of pulmonary arterial hypertension

N Sommer, HA Ghofrani, O Pak… - British journal of …, 2021 - Wiley Online Library
Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Advances in therapeutic interventions for patients with pulmonary arterial hypertension

M Humbert, EMT Lau, D Montani, X Jaïs, O Sitbon… - Circulation, 2014 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a disease characterized by progressive
remodeling of the distal pulmonary arteries, resulting in the loss of vascular cross-sectional …