Biocatalysis for pharmaceutical intermediates: the future is now

DJ Pollard, JM Woodley - TRENDS in Biotechnology, 2007 - cell.com
Biocatalysis is continuing to gain momentum and is now becoming a key component in the
toolbox of the process chemist, with a place alongside chemocatalysis and chromatographic …

Enzymatic reductions for the chemist

F Hollmann, IWCE Arends, D Holtmann - Green Chemistry, 2011 - pubs.rsc.org
When challenged by a difficult reduction reaction, a chemist should always also consider
biocatalysis in synthesis planning. The inherent selectivity of enzymes has been known for …

Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

W Van Hecke, G Kaur, H De Wever - Biotechnology advances, 2014 - Elsevier
The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR)
in whole-cell biotechnology over the last 10 years. It summarizes various ISPR-integrated …

Reactive crystallization: a review

MA McDonald, H Salami, PR Harris… - Reaction Chemistry & …, 2021 - pubs.rsc.org
Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …

Process intensification as game changer in enzyme catalysis

BO Burek, AWH Dawood, F Hollmann, A Liese… - Frontiers in …, 2022 - frontiersin.org
Enzyme catalysis, made tremendous progress over the last years in identification of new
enzymes and new enzymatic reactivity's as well as optimization of existing enzymes …

Future directions for in‐situ product removal (ISPR)

JM Woodley, M Bisschops… - Journal of Chemical …, 2008 - Wiley Online Library
This paper summarizes the main findings of a round‐table discussion held to examine the
key bottlenecks in the further application and industrial implementation of in‐situ product …

Integrated bioprocesses

K Schügerl, J Hubbuch - Current opinion in microbiology, 2005 - Elsevier
Integrated bioprocesses have been developed to optimise yield and cost-effectiveness of
production of low and high molecular weight molecules. Low molecular weight products are …

Application of in situ product crystallization and related techniques in biocatalytic processes

D Hülsewede, LE Meyer… - Chemistry–A European …, 2019 - Wiley Online Library
This Minireview highlights the application of crystallization as a very powerful in situ product
removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its …

The locks and keys to industrial biotechnology

R Wohlgemuth - New Biotechnology, 2009 - Elsevier
The sustainable use of resources by Nature to synthesize the required products at the right
place, when they are needed, continues to be the role model for total synthesis and …

Co-crystallization as a separation technology: controlling product concentrations by co-crystals

J Urbanus, CPM Roelands, D Verdoes… - Crystal growth & …, 2010 - ACS Publications
Co-crystallization is known as a product formulation technology, but it can also be used as a
tool to solve crystallization problems. Product removal by co-crystallization in fermentations …