Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide,
causing pain, disability, and decreased quality of life. The balance between regeneration …

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems, especially type II (Cas9) systems, have been widely developed for …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

Malaria caused by Plasmodium is still a serious public health problem. Genomic editing is
essential to understand parasite biology, elucidate mechanical pathways, uncover gene …

Clustered regularly interspaced short palindromic repeats–Cas13 effectors are used for
RNA editing but the adeno-associated virus (AAV) packaging limitations because of their big …

Prokaryotes are equipped with a variety of resistance strategies to survive frequent viral
attacks or invading mobile genetic elements. Among these, CRISPR–Cas surveillance …

This review is devoted to changes in the post-transcriptional maturation of RNA in human
glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The …

Current gene silencing tools based on RNA interference (RNAi) or, more recently, clustered
regularly interspaced short palindromic repeats (CRISPR)‒Cas13 systems have critical …

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated (Cas) proteins constitute the innate adaptive immune system in several bacteria …

Rare genetic diseases reduce quality of life and can significantly shorten the lifespan. There
are few effective treatment options for these diseases, and existing therapeutic strategies …