Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress
made over the past decade in cancer medicine our understanding of metastasis remains …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint
inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for …

Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer
but their contribution to metastasis is not well defined. Using mouse models with tagged …

Results A total of 243,896 patients, including 226,451 cases in control groups were
identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis …

Metastasis and chemoresistance in cancer are linked phenomena, but the molecular basis
for this link is unknown. We uncovered a network of paracrine signals between carcinoma …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …

Purpose Prognostic and predictive factors are well established in early-stage breast cancer,
but less is known about which metastatic sites will be affected. Methods Patients with early …

Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely
different effects in various target organs. Here we show that tumour-secreted DKK1 is a …