Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental
disorder of childhood. It is primarily characterised by high levels of activity, inattention, and …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Abstract Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-
BOX family, is involved in embryonic brain development, neuronal formation and …

The rapidly acting antidepressants ketamine and scopolamine exert behavioral effects that
can last from several days to more than a week in some patients. The molecular …

Recent increases in human longevity have been accompanied by a rise in the incidence of
dementia, highlighting the need to preserve cognitive function in an aging population. A …

Numerous genetic variants associated with MEF2C are linked to autism, intellectual
disability (ID) and schizophrenia (SCZ)–a heterogeneous collection of neurodevelopmental …

Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast
amounts of molecular information, with largely unexplored therapeutic potential. We …

Cortico-basal ganglia circuits are critical for speech and language and are implicated in
autism spectrum disorder, in which language function can be severely affected. We …

Fear-related disorders arise from inefficient fear extinction and have immeasurable social
and economic costs. Here, we characterize mouse phenotypes that spontaneously show …

Highlights•MEF2s control gene expression in the developing and adult brain.•MEF2s
regulate synaptic plasticity during critical periods of brain development.•Sensory …