The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

Organisms have cellular machinery that is focused on optimum utilization of resources to
maximize growth and survival depending on various environmental and developmental …

Cyclic dimeric AMP (c-di-AMP) is a widespread second messenger that controls such key
functions as osmotic homeostasis, peptidoglycan biosynthesis, and response to various …

Bacteria respond to changes in environmental conditions through adaptation to external
cues. Frequently, bacteria employ nucleotide signaling molecules to mediate a specific …

The bacterial pathogen Staphylococcus aureus is capable of infecting a broad spectrum of
host tissues, in part due to flexibility of metabolic programs. S. aureus, like all organisms …

Community-associated and hospital-acquired infections caused by bacteria continue to yield
major global challenges to human health. Bacterial contamination on abiotic surfaces is …

In order to adjust to changing environmental conditions, bacteria use nucleotide second
messengers to transduce external signals and translate them into a specific cellular …

Cystic fibrosis (CF) disease is characterized by lifelong infections with pathogens such as
Staphylococcus aureus, leading to eventual respiratory failure. Small colony variants (SCVs) …

Staphylococcus aureus is a major pathogen, which has to defend against reactive oxygen
and electrophilic species encountered during infections. Activated macrophages produce …

Genome sequencing has demonstrated that Staphylococcus aureus encodes arginine
biosynthetic genes argDCJBFGH synthesizing proteins that mediate arginine biosynthesis …