Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

[HTML][HTML] Current status of COVID-19 therapies and drug repositioning applications

O Altay, E Mohammadi, S Lam, H Turkez, J Boren… - Iscience, 2020 - cell.com
The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an
immediate urgency to discover promising targets for the treatment of COVID-19. Drug …

Targeting reactive oxygen species capacity of tumor cells with repurposed drug as an anticancer therapy

J Wang, D Sun, L Huang, S Wang… - Oxidative medicine and …, 2021 - Wiley Online Library
Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Drug repositioning: A bibliometric analysis

G Sun, D Dong, Z Dong, Q Zhang, H Fang… - Frontiers in …, 2022 - frontiersin.org
Drug repurposing has become an effective approach to drug discovery, as it offers a new
way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social …

Decoding Connectivity Map-based drug repurposing for oncotherapy

Y Zhao, X Chen, J Chen, X Qi - Briefings in Bioinformatics, 2023 - academic.oup.com
The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …

Pan-cancer mapping of differential protein-protein interactions

G Gulfidan, B Turanli, H Beklen, R Sinha, KY Arga - Scientific reports, 2020 - nature.com
Deciphering the variations in the protein interactome is required to reach a systems-level
understanding of tumorigenesis. To accomplish this task, we have considered the clinical …

Side effect prediction based on drug-induced gene expression profiles and random forest with iterative feature selection

A Cakir, M Tuncer, H Taymaz-Nikerel… - The Pharmacogenomics …, 2021 - nature.com
One in every ten drug candidates fail in clinical trials mainly due to efficacy and safety
related issues, despite in-depth preclinical testing. Even some of the approved drugs such …

Drug repositioning in cancer: The current situation in Japan

T Masuda, Y Tsuruda, Y Matsumoto, H Uchida… - Cancer …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide, and the incidence continues to increase.
Despite major research aimed at discovering and developing novel and effective anticancer …

Potential Anticancer Activity of Pomegranate (Punica granatum L.) Fruits of Different Color: In Vitro and In Silico Evidence

MC Cortez-Trejo, FJ Olivas-Aguirre, E Dufoo-Hurtado… - Biomolecules, 2022 - mdpi.com
Pomegranate (PMG; Punica granatum L.) fruits possess a well-balanced
nutrient/phytochemical composition, with proven adjuvant benefits in experimental cancer …

Systems biology: new insight into antibiotic resistance

P Francine - Microorganisms, 2022 - mdpi.com
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important
threat to public health, resulting from the global propagation of multidrug-resistant strains of …