Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

Summary Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …

Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been
implicated as tumor suppressors in human malignancies. To understand the full extent of …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …