The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …

Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various
diseases, including infection and sepsis. Although studies suggest that mitochondria may …

Pluripotent cells from the early stages of embryonic development have the unlimited
capacity to self-renew and undergo differentiation into all of the cell types of the adult …

Mitophagy is the selective autophagic targeting and removal of dysfunctional mitochondria.
While PINK1/Parkin-dependent mitophagy is well-characterized, PINK1/Parkin-independent …

Mitochondria is not only a dynamic organelle that produces ATP, but is also an important
contributor to cell functions in both development and cell death processes. These …

Abnormal heart development is a key feature contributing to the cardiac defects of
congenital heart diseases, which are the most common birth defects in humans, occurring in …