The Tet repressor protein (TetR) regulates transcription of a family of tetracycline (tc)
resistance determinants in Gram‐negative bacteria. The resistance protein TetA, a …

▪ Abstract The prospect of specifically controlling gene activities in vivo has become a
defining hallmark of many model organisms of biological research. Where once the aim was …

Conventional tools for elucidating gene function are relatively scarce in Candida albicans,
the most prevalent human fungal pathogen. To this end, we developed a convenient system …

We designed experiments to assess whether fungal cell wall mannans function as an
immune shield or an immune agonist. Fungal cell wall β-(1, 3)-glucan normally plays a …

In the pathogenic yeast Candida glabrata, gene targeting to generate knockouts and
“knockins” is a potentially powerful method for the analysis of gene function. Its importance …

▪ Abstract The frequency of opportunistic infections caused by the fungus Candida albicans
is very high and is expected to continue to increase as the number of immunocompromised …

Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat.
Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C …

Objectives The uptake of endogenous sterol from serum may allow Candida glabrata to
survive azole treatment. This study aims to determine the contribution of a sterol transporter …

Abstract Background Although Aspergillus fumigatus is an important human fungal
pathogen there are few expression systems available to study the contribution of specific …

The highly conserved fungal Ste12 transcription factor family of proteins play critical roles in
the regulation of many cellular processes including mating, cell wall biosynthesis …