Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor
sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification …

Fucosylated carbohydrate structures are involved in a variety of biological and pathological
processes in eukaryotic organisms including tissue development, angiogenesis, fertilization …

The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …

Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Potent inhibitors of fucosyltransferases, and glycosyltransferases in general, have been
elusive due to the inherent barriers surrounding the family of glycosyltransfer reactions. The …

Identifying the functional roles of carbohydrates in biological systems has been an area of
intense study in recent years. Although carbohydrates were once viewed only as inert …

Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

The enzymes involved in the biosynthesis of carbohydrates and the attachment of sugar
units to biological acceptor molecules catalyse an array of chemical transformations and …

The high-resolution X-ray crystal structures of a new form of bacteriophage T4 β-
glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine β-1, 4 …