Small animal PET: a review of what we have done and where we are going

RS Miyaoka, AL Lehnert - Physics in Medicine & Biology, 2020 - iopscience.iop.org
Small animal research is an essential tool in studying both pharmaceutical biodistribution
and disease progression over time. Furthermore, through the rapid development of in vivo …

[HTML][HTML] Consequences of metabolic disruption in Alzheimer's disease pathology

JC Ryu, ER Zimmer, P Rosa-Neto, SO Yoon - Neurotherapeutics, 2019 - Elsevier
Alzheimer's disease (AD) is an irreversible, progressive disease that slowly destroys
cognitive function, such as thinking, remembering, and reasoning, to a level that one cannot …

Evolution of PET detectors and event positioning algorithms using monolithic scintillation crystals

A Gonzalez-Montoro, AJ Gonzalez… - … on Radiation and …, 2021 - ieeexplore.ieee.org
The use of monolithic scintillator-based photon detectors in positron emission tomography
(PET) has emerged as an attractive alternative to traditional pixelated array designs …

Performance evaluation of the MOLECUBES β-CUBE—a high spatial resolution and high sensitivity small animal PET scanner utilizing monolithic LYSO scintillation …

S Krishnamoorthy, E Blankemeyer… - Physics in Medicine …, 2018 - iopscience.iop.org
The MOLECUBES β-CUBE scanner is the newest amongst commercially available
preclinical PET scanners for dedicated small animal imaging. The scanner is compact …

Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice

M Brilkova, M Nigri, HS Kumar, J Moore, M Mantovani… - Cell reports, 2022 - cell.com
Age-related neurodegenerative diseases (NDDs) are associated with the aggregation and
propagation of specific pathogenic protein species (eg, Aβ, α-synuclein). However, whether …

[HTML][HTML] ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges

F Verhaegen, L Dubois, S Gianolini, MA Hill… - Radiotherapy and …, 2018 - Elsevier
Many radiotherapy research centers have recently installed novel research platforms
enabling the investigation of the radiation response of tumors and normal tissues in small …

A prototype high-resolution small-animal PET scanner dedicated to mouse brain imaging

Y Yang, J Bec, J Zhou, M Zhang… - Journal of Nuclear …, 2016 - Soc Nuclear Med
We developed a prototype small-animal PET scanner based on depth-encoding detectors
using dual-ended readout of small scintillator elements to produce high and uniform spatial …

DigiPET: sub-millimeter spatial resolution small-animal PET imaging using thin monolithic scintillators

S España, R Marcinkowski, V Keereman… - Physics in Medicine …, 2014 - iopscience.iop.org
A new preclinical PET system based on dSiPMs, called DigiPET, is presented. The system is
based on thin monolithic scintillation crystals and exhibits superior spatial resolution at low …

Preclinical imaging: an essential ally in modern biosciences

L Cunha, I Horvath, S Ferreira, J Lemos… - Molecular diagnosis & …, 2014 - Springer
Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …

Small-animal PET: what is it, and why do we need it?

R Yao, R Lecomte, ES Crawford - Journal of nuclear medicine …, 2012 - Soc Nuclear Med
Small-animal PET refers to imaging of animals such as rats and mice using dedicated PET
scanners. Small-animal PET has been used extensively in modern biomedical research. It …