Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

Advanced breast cancer responds to a range of cytotoxic agents, but resistance always
develops. Understanding the mechanisms of resistance may provide new therapeutic …

The extreme length of DNA molecules as well as the structural attachment of the DNA to a
structural matrix in the nuclei of eukaryotic cells are responsible for the topological …

A mutant yeast type II topoisomerase was generated by in vitro mutagenesis followed by
selection in vivo for resistance to the quinolone CP-115,953. The resulting mutant enzyme …

The type II DNA topoisomerases are targets for a variety of chemotherapeutic agents,
including the antibacterial quinolones and several families of antitumor drugs. These agents …

Publisher Summary The type II enzyme of topoisomerases is required for proper
chromosome structure and segregation, is involved in processes of DNA metabolism, and is …

Type II topoisomerases are the targets of several classes of chemotherapeutic agents that
stabilize an intermediate of the catalytic cycle with the enzyme covalently linked to cleaved …

Numerous antitumor and antibacterial agents inhibit type II DNA topoisomerases, yielding, in
each case, a complex of enzyme covalently bound to cleaved DNA. We are investigating the …

Amsacrine is an effective topoisomerase II enzyme inhibitor in acute lymphatic leukemia.
Previous experimental studies have successfully identified two important mutations (R487K …

Topoisomerase II is a nuclear enzyme which permits chromosomal dysjunction at the
termination of DNA synthesis by the breakage and religation of DNA with an intermediary …