Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic
function at early stages of cancer formation and pro-tumorigenic effects at later stages …

Gliomas are the most frequent brain tumors in the adult population and unfortunately the
adjuvant therapies are not effective. Brain tumorigenesis has been related both to the …

Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate
due to its infiltrative growth, treatment resistance, intra-and intertumoral genetic …

Simple Summary Glioblastoma multiforme (GBM) is one of the belligerent neoplasia that
metastasize to other brain regions and invade nearby healthy tissues. However, the …

Simple Summary Glioblastoma (GB) is the most aggressive brain tumor characterized by
necrosis, excessive proliferation, and invasiveness. Despite relevant progress in …

The anticancer effect of manumycin A (Man A) has been attributed to the inhibition of
farnesyl transferase (FTase), an enzyme that is responsible for post-translational …

Mitochondrial transcription factor A (TFAM) is a key regulator of mitochondria biogenesis.
Previous studies confirmed that reduced TFAM expression sensitized tumours cells to …

The activities of two effectors, brevetoxin (PbTx) and manumycin-A (Man-A), of thioredoxin
reductase (TrxR) have been evaluated against a series of fourteen TrxR orthologs …

Natural podophyllotoxin (PODO) is an anticancer drug that functions as an anti-mitotic agent
and inhibits tubulin polymerization. However, high toxicity and low bioavailability limit its …

Background We previously reported up-regulation of tigarb (the zebrafish orthologue of
human TIGAR, TP53–Induced Glycolysis and Apoptosis Regulator) in a zebrafish pink1 …