Solid lipid nanoparticles (SLNs): an advanced drug delivery system targeting brain through BBB

MK Satapathy, TL Yen, JS Jan, RD Tang, JY Wang… - Pharmaceutics, 2021 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of
homeostasis in the brain. In this way, it is an interesting target as an interface for various …

Microglia autophagy in ischemic stroke: A double-edged sword

L Peng, G Hu, Q Yao, J Wu, Z He, BYK Law… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing
neurological morbidity and mortality worldwide. In the pathophysiological process of IS …

Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease

S Toniolo, A Sen, M Husain - International journal of molecular sciences, 2020 - mdpi.com
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Advanced drug delivery system against ischemic stroke

S Zhang, Y Zhou, R Li, Z Chen, X Fan - Journal of Controlled Release, 2022 - Elsevier
Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage

LT Hu, BY Wang, YH Fan, ZY He… - Neural regeneration …, 2023 - journals.lww.com
Our previous studies showed that miR-23b was downregulated in patients with intracerebral
hemorrhage (ICH). This indicates that miR-23b may be closely related to the patho …

Tissue acidosis associated with ischemic stroke to guide neuroprotective drug delivery

O M. Tóth, Á Menyhárt, R Frank, D Hantosi, E Farkas… - Biology, 2020 - mdpi.com
Simple Summary Ischemic stroke is caused by the blockade of a blood vessel in the brain.
Consequently, the brain region supplied by the blocked vessel suffers brain damage and …

Silk fibroin: An ancient material for repairing the injured nervous system

M Yonesi, M Garcia-Nieto, GV Guinea, F Panetsos… - Pharmaceutics, 2021 - mdpi.com
Silk refers to a family of natural fibers spun by several species of invertebrates such as
spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has …

Excitatory synaptic transmission in ischemic stroke: a new outlet for classical neuroprotective strategies

F Wang, X Xie, X Xing, X Sun - International Journal of Molecular …, 2022 - mdpi.com
Stroke is one of the leading causes of death and disability in the world, of which ischemia
accounts for the majority. There is growing evidence of changes in synaptic connections and …

Neurotrophic factor-based pharmacological approaches in neurological disorders

M Alfonsetti, M d'Angelo, V Castelli - Neural regeneration …, 2023 - journals.lww.com
Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …

Marine biocompounds for neuroprotection—A review

AF Bălașa, C Chircov, AM Grumezescu - Marine Drugs, 2020 - mdpi.com
While terrestrial organisms are the primary source of natural products, recent years have
witnessed a considerable shift towards marine-sourced biocompounds. They have achieved …