Conclusion Herein, we comprehensively review and refine the clinical hallmarks uniquely
associated with ICI therapies, which not only will rejuvenate our assessment of ICI …

Observational pharmacoepidemiological studies using routinely collected healthcare data
are increasingly being used in the field of nephrology to answer questions on the …

PURPOSE The anti-CD19 chimeric antigen receptor T-cell therapy tisagenlecleucel
(CTL019) has an 81% response rate in children with relapsed or chemotherapy refractory …

Rationale & Objective Renin-angiotensin-aldosterone system (RAAS) inhibitors are
evidence-based therapies that slow the progression of chronic kidney disease (CKD) but …

Background COVID-19 vaccines provide protection against symptomatic infection that might
require medical attention and against severe outcomes; however, there is a paucity of …

The epidemiologic study of pregnancy and birth outcomes may be hindered by several
unique and challenging issues. Pregnancy is a time-limited period in which severe cohort …

Background Whether oral anticoagulation (OAC) can prevent dementia or cognitive
impairment (CI) in patients with atrial fibrillation (AF) remains unclear. Objective The purpose …

Importance National guidelines recommend cardiac rehabilitation (CR) after cardiac valve
surgery, and CR is covered by Medicare for this indication. However, few data exist …

The objectives of this study are to illustrate the effects of immortal time bias (ITB) using an
oncology outcomes database and quantify through simulations the magnitude and direction …

Purpose: The optimal sequence of cytoreductive nephrectomy and targeted therapy of
metastatic renal cell carcinoma is unclear. We compared overall survival between patients …