Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Background Vascular calcification is an indicator of elevated cardiovascular risk. Vascular
smooth muscle cells (VSMCs), the predominant cell type involved in medial vascular …

Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility.
Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer …

Podoplanin is a small mucin-like transmembrane protein expressed in several adult tissues
and with an important role during embryogenesis. It is needed for the proper development of …

Cancer is a leading cause of death of men and women worldwide. Tumor cell motility
contributes to metastatic invasion that causes the vast majority of cancer deaths …

Cancer-associated fibroblasts (CAFs) are well-known to be part of the tumor
microenvironment. This heterogeneous population of cells of the tumor microenvironment …

Podoplanin is a transmembrane glycoprotein that is upregulated in cancer and was reported
to induce an epithelial-mesenchymal transition (EMT) in MDCK cells. The promotion of EMT …

Highlights•Cancer kills over 8 million people each year, and arthritis affects over 300
million.•Both cancer and arthritis involve tissue degradation, invasion, and …

Podoplanin is highly expressed in human cancers. However, mechanisms regulating
podoplanin expression remain elusive. Here we show that podoplanin promotes …