About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Context Premature ovarian insufficiency (POI) is a common form of female infertility that
usually presents as an isolated condition but can be part of various genetic syndromes …

Premature ovarian insufficiency (POI) is a common cause of infertility in women,
characterised by amenorrhea and elevated FSH under the age of 40 years. In some cases …

Inborn errors of immunity (IEI), caused by hereditary or genetic defects, are a group of more
than 400 disorders, in which the immune system, including lymphocytes, neutrophils …

The congenital neutropenia syndromes are rare haematological conditions defined by
impaired myeloid precursor differentiation or function. Patients are prone to severe infections …

HAX1‐related congenital neutropenia (HAX1‐CN) is a rare autosomal recessive disorder
caused by pathogenic variants in the HAX1 gene. HAX1‐CN patients suffer from bone …

Premature ovarian insufficiency (POI) is a group of heterogeneous disorders characterized
by decreased ovarian reserve and increased follicle stimulating hormone (FSH) levels. It is …

Background: Severe congenital neutropenia (SCN), also known as Kostmann syndrome, is
a rare heterogeneous group of diseases characterized by arrested neutrophil maturation in …

Background HAX-1 is involved in the regulation of cellular processes such as apoptosis,
proliferation and migration and is closely related to tumorigenesis and tumor metastasis …