Emotional arousal is a complex state recruiting distributed cortical and subcortical structures,
in which the amygdala and insula play an important role. Although previous neuroimaging …

Major depressive disorder (MDD) with childhood maltreatment is a heterogeneous clinical
phenotype of depression with prominent features of brain disconnectivity in areas linked to …

Background Childhood maltreatment (CM) is a major risk factor for the development of major
depressive disorder (MDD). To gain more knowledge on how adverse childhood …

Anxiety is elicited by excessive apprehension about unpredictable threats. However, the
neural circuit governing unpredictable threat induced anxiety remains unclear. Here, we …

Background The sex differences were co-shaped by innate biological differences and social
environment, and were frequently observed in human emotional neural responses. Oral …

Background: Childhood emotional neglect (CEN) confers a great risk for developing multiple
psychiatric disorders; however, the neural basis for this association remains unknown. Using …

Background: Initial evidence proposes that exposure to childhood adversity may induce
avoidance or withdrawal behaviour. However, it remains unclear whether childhood …

Introduction Adverse life events constitute primary risk factors for major depressive disorder
(MDD), influencing brain function and structure. Adolescents, with their brains undergoing …

Childhood maltreatment is an established risk factor for psychopathology. However, it
remains unclear how childhood traumatic events relate to mental health problems and how …

Background Childhood abuse (physical, emotional, and sexual) is associated with aberrant
connectivity of the amygdala, a key threat-processing region. Heightened amygdala activity …