Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs

I Olmedo, D Martínez, J Carrasco-Rojas, JA Jara - Life Sciences, 2023 - Elsevier
Head and neck cancer is a major health problem worldwide, with most cases arising in the
oral cavity. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer …

Hallmarks of cancer expression in oral lichen planus: a scoping review of systematic reviews and meta-analyses

MÁ González-Moles, C Keim-del Pino… - International Journal of …, 2022 - mdpi.com
Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology
and likely autoimmune nature that is currently considered an oral potentially malignant …

Can CD133 Be Regarded as a Prognostic Biomarker in Oncology: Pros and Cons

A Gisina, Y Kim, K Yarygin, A Lupatov - International Journal of Molecular …, 2023 - mdpi.com
The CD133 cell membrane glycoprotein, also termed prominin-1, is expressed on some of
the tumor cells of both solid and blood malignancies. The CD133-positive tumor cells were …

Promoter methylation of cancer stem cell surface markers as an epigenetic biomarker for prognosis of oral squamous cell carcinoma

YK Han, HY Park, SG Park, JJ Hwang… - International Journal of …, 2022 - mdpi.com
Growing evidence suggests that genetic and epigenetic factors, including environmental
factors, contribute to the development of oral squamous cell carcinoma (OSCC). Here, we …

Targeting the genetic landscape of oral potentially malignant disorders has the potential as a preventative strategy in oral cancer

SS Prime, N Cirillo, SC Cheong, MS Prime… - Cancer letters, 2021 - Elsevier
This study reviews the molecular landscape of oral potentially malignant disorders (OPMD).
We examine the impact of tumour heterogeneity, the spectrum of driver mutations (TP53 …

Development of a multifunctional gold nanoplatform for combined chemo-photothermal therapy against oral cancer

Z Liu, J Shi, B Zhu, Q Xu - Nanomedicine, 2020 - Taylor & Francis
Aim: To design and fabricate a multifunctional drug-delivery nanoplatform for oral cancer
therapy. Materials & methods: Polyethylene glycol-stabilized, PDPN antibody (PDPN Ab) …

Overexpression of RRM2 is related to poor prognosis in oral squamous cell carcinoma

S Wang, XL Wang, ZZ Wu, QC Yang, HG Xiong… - Oral …, 2021 - Wiley Online Library
Abstract Objectives Ribonucleotide reductase M2 (RRM2) is a rate‐limiting enzyme involved
in DNA repair and synthesis. This study aimed to investigate the expression level …

Podoplanin expression independently and jointly with oral epithelial dysplasia grade acts as a potential biomarker of malignant transformation in oral leukoplakia

L Monteiro, B Do Amaral, L Delgado, F Garcês… - Biomolecules, 2022 - mdpi.com
Our aim was to evaluate the expression of biomarkers, CD44v6, CD147, EGFR, p53, p63,
p73, p16, and podoplanin in oral leukoplakias (OL) and to assess their potential for …

[HTML][HTML] Preliminary Study of the Cancer Stem Cells' Biomarker CD147 in Leukoplakia: Dysplasia and Squamous Cell Carcinoma of Oral Epithelial Origin

V Zisis, D Andreadis, P Anastasiadou, K Vahtsevanos… - Cureus, 2023 - ncbi.nlm.nih.gov
Objectives Cancer stem cells (CSCs) are responsible for initiating the process of
carcinogenesis de novo, as well as through the transformation of oral potential malignant …

Mitochondrial stress–mediated targeting of quiescent cancer stem cells in Oral squamous cell carcinoma

TS Saluja, V Kumar, M Agrawal, A Tripathi… - Cancer management …, 2020 - Taylor & Francis
Introduction Despite improved therapeutics in oral squamous cell carcinoma (OSCC), tumor
cells that are either quiescent and/or endowed with stem cell–like attributes usually survive …