Mechanical stretch is widely experienced by cells of different tissues in the human body and
plays critical roles in regulating their behaviors. Numerous studies have been devoted to …

Pulmonary fibrosis is an often fatal lung disease. Immune cells such as macrophages were
shown to accumulate in the fibrotic lung, but their contribution to the fibrosis development is …

Adult stem cells play a critical role in maintaining tissue homeostasis and promoting
longevity. The intricate organization and presence of common markers among adult …

Pulmonary fibrosis leads to increased mortality but is poorly understood. Fibrotic
progression is associated with abnormal wound repair and an increase in myofibroblast cell …

The high attrition rate of drug candidates contributes to the long duration and high cost in
modern drug development. A major barrier in drug development is the poor predicting power …

Myofibroblasts are mechanosensitive cells and a variety of their behaviours including
differentiation, migration, force production and biosynthesis are regulated by the …

Tissue fibrosis is a major health issue that impacts millions of people and is costly to treat.
However, few effective anti-fibrotic treatments are available. Due to their central role in …

There is often a tradeoff between in vitro disease modeling platforms that capture
pathophysiologic complexity and those that are amenable to high-throughput fabrication and …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder with a low survival rate.
Pulmonary fibrosis is one of the complications of COVID-19 and has a high prevalence in …

Cells are sensitive to their surrounding microenvironment. The microscopic length scale of
single cells makes it challenging to study how cells sense, interpret, and transform complex …