Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

Skeletal muscle fibers have a unique capacity to adjust their metabolism and phenotype in
response to alternations in mechanical loading. Indeed, chronic mechanical loading leads to …

Several publications report that octacosanol (OCT) has different biological functions. This
study was designed to evaluate the antifatigue effect and molecular mechanism of …

Skeletal muscle atrophy continues to be a serious consequence of many diseases and
conditions for which there is no treatment. Our understanding of the mechanisms regulating …

Objective Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the
methylation of arginine residues on target proteins to regulate critical processes in health …

The muscle-specific ring finger protein 1 (MuRF1) gene is required for most types of skeletal
muscle atrophy yet we have little understanding of its transcriptional regulation. The purpose …

P-Rex1 (PIP3-dependent Rac exchanger 1, PREX1) is a Dbl-type guanine-nucleotide
exchange factor (GEF) that activates Rac-like small G proteins (small GTPases). P-Rex1 was …

Existing data suggest that NF-kappaB signaling is a key regulator of cancer-induced skeletal
muscle wasting. However, identification of the components of this signaling pathway and of …

Protein lysine acetylation is a post-translational modification that regulates protein structure
and function. It is targeted to proteins by lysine acetyltransferases (KATs) or removed by …

The inhibitory IκB family of proteins is subdivided into two groups based on protein
localization in the cytoplasm or in the nucleus. These proteins interact with NF-κB, a major …