Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit
E Nickles, B Dharmadhikari, L Yating, RJ Walsh… - Cancer Immunology …, 2022 - Springer
Abstract Introduction Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma
(NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) …
(NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) …
CD137-expressing regulatory T cells in cancer and autoimmune diseases
KY Lee, Y Mei, H Liu, H Schwarz - Molecular Therapy, 2025 - cell.com
Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, with critical
roles in preventing aberrant immune responses that occur in autoimmune diseases and …
roles in preventing aberrant immune responses that occur in autoimmune diseases and …
CD137 Ligand-CD137 interaction is required for inflammasome-associated brain injury following ischemic stroke
Abstract The CD137L-CD137 axis is a potent co-stimulatory immune checkpoint regulator
that forms a bidirectional signaling pathway between the CD137 ligand (CD137L) and …
that forms a bidirectional signaling pathway between the CD137 ligand (CD137L) and …
Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
KY Lee, HY Wong, Q Zeng, J Le Lin, MS Cheng… - …, 2021 - Taylor & Francis
Rhabdomyosarcoma (RMS) is a heterogeneous soft tissue neoplasm most frequently found
in children and adolescents. As the prognosis for recurrent and metastatic RMS remains …
in children and adolescents. As the prognosis for recurrent and metastatic RMS remains …
CD137L promotes immune surveillance in melanoma via HLTF regulation
H Liu, L Liang, L Zhu, X Li, GX Zhang, X Kuang… - 2024 - researchsquare.com
Immune checkpoint blockers (ICBs) have shown considerable effect in a number of
malignancies. However, only limited patients were responsive to ICBs. Therefore, it is critical …
malignancies. However, only limited patients were responsive to ICBs. Therefore, it is critical …
CD137L, a driver of harmful inflammation in the nervous system
CD137 (TNFRSF9, 4-1BB) is a member of the tumor necrosis factor (TNF) receptor family
and a potent costimulatory molecule. High levels of CD137 are expressed on T cells upon …
and a potent costimulatory molecule. High levels of CD137 are expressed on T cells upon …