Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

When aberrant, factors critical for organ morphogenesis are also commonly involved in
disease progression. FOXA1 (forkhead box A1), also known as HNF3α (hepatocyte nuclear …

Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …

Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …

Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …

The specification of the vertebrate liver is thought to occur in a two-step process, beginning
with the establishment of competence within the foregut endoderm for responding to organ …

Estrogen stimulates the proliferation of the most common type of human breast cancer that
expresses estrogen receptor α (ERα) through the activation of the cyclin D1 (CCND1) …

Estrogen receptor (ER) functions as a transcription factor to induce gene expression events
sufficient for cell division and breast cancer progression. A significant body of work exists on …

Simple Summary Factors such as estrogen, progesterone, and androgen receptors, also
known as nuclear receptors, are abundantly expressed in the majority of breast cancers …

During embryonic development, Foxa2 is required for the formation of the node and
notochord, and ablation of this gene results in defects in gastrulation, neural tube patterning …