What to do when you question cardiac troponin values

J Mair, B Lindahl, C Müller… - … heart journal: acute …, 2018 - journals.sagepub.com
High-sensitivity cardiac troponin assays enable cardiac troponin measurement with a high
degree of analytical sensitivity and a low level of analytical imprecision at the low measuring …

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function

B Wei, JP Jin - Archives of biochemistry and biophysics, 2011 - Elsevier
Troponin-mediated Ca2+-regulation governs the actin-activated myosin motor function
which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the …

Development and in vitro characterization of a new immunoassay of cardiac troponin T

HA Katus, S Looser, K Hallermayer… - Clinical …, 1992 - academic.oup.com
We describe a new one-step enzyme immunoassay of troponin T that uses two specific
monoclonal antibodies and streptavidin-coated tubes as the solid phase. The monoclonal …

Cardiac troponin T composition in normal and regenerating human skeletal muscle

GS Bodor, L Survant, EM Voss, S Smith… - Clinical …, 1997 - academic.oup.com
Cardiac troponin T (cTnT), measurement of which has been recommended for diagnosing
myocardial infarction, was initially believed to be specific for the heart. However, recent …

Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction

D Rittoo, A Jones, B Lecky, D Neithercut - Journal of the American college …, 2014 - jacc.org
Objectives: This study sought to determine the clinical and biological significance of
elevated cardiac troponin T (cTnT) in patients with neuromuscular diseases. Background …

Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay

PJ O'Brien, Y Landt, JH Ladenson - Clinical Chemistry, 1997 - academic.oup.com
To identify a blood test that can differentiate cardiac from skeletal muscle injury in animals,
we compared tissue reactivities for various species with the use of an immunoassay for …

Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model

D Franco, WH Lamers… - Cardiovascular research, 1998 - academic.oup.com
The heart is the first embryonic organ to function. Early in development, the heart shows
autorhythmycity and periwx staltoid contraction waves 1, 2. Contraction requires the …

Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction

AH Wu, R Valdes Jr, FS Apple, T Gornet… - Clinical …, 1994 - academic.oup.com
We evaluated the analytical and clinical performance of an immunoassay for cardiac
troponin T (cTnT). Within-run and total imprecision ranged from 1.6 to 11.3%. The sensitivity …

Myocardial Markers of Injury: Evolution and Insights

JH Keffer - American journal of clinical pathology, 1996 - academic.oup.com
Abstract Knowledge of the pathophysiology of ischemic heart disease has advanced in
parallel with awareness of the significant limitations inherent in clinical assessment …

Proteins of the troponin complex

HA Katus, T Scheffold, A Remppis… - Laboratory …, 1992 - academic.oup.com
The troponin complex is a group of three protein subunits located on the thin filament of the
contractile apparatus. These three subunits—troponin T, troponin I, and troponin C …