Uncovering the Hidden Credentials of Brucella Virulence

RM Roop, IS Barton, D Hopersberger… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Rough vaccines in animal brucellosis: structural and genetic basis and present status

I Moriyón, M Grilló, D Monreal, D González… - Veterinary …, 2004 - hal.science
-Brucellosis control and eradication requires serological tests and vaccines. Effective
classical vaccines (S19 in cattle and Rev 1 in small ruminants), however, induce antibodies …

Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system

PG Cardoso, GC Macedo, V Azevedo, SC Oliveira - Microbial cell factories, 2006 - Springer
Brucella spp. are facultative intracellular pathogens that have the ability to survive and
multiply in professional and non-professional phagocytes, and cause abortion in domestic …

Development and trial of vaccines against Brucella

J Lalsiamthara, JH Lee - Journal of Veterinary Science, 2017 - synapse.koreamed.org
The search for ideal brucellosis vaccines remains active today. Currently, no licensed
human or canine anti-brucellosis vaccines are available. In bovines, the most successful …

The advances in brucellosis vaccines

H Hou, X Liu, Q Peng - Vaccine, 2019 - Elsevier
Brucellosis is a worldwide zoonosis affecting animal and human health. Till now, there is no
effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines …

Efficacy of several serological tests and antigens for diagnosis of bovine brucellosis in the presence of false-positive serological results due to Yersinia enterocolitica …

PM Muñoz, CM Marín, D Monreal… - Clinical and Vaccine …, 2005 - Am Soc Microbiol
Yersinia enterocolitica O: 9 bears a smooth lipopolysaccharide (S-LPS) of Brucella sp. O-
chain A+ C/Y epitopic structure and is a cause of false-positive serological reactions (FPSR) …

The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition

R Conde-Alvarez, V Arce-Gorvel, M Iriarte… - PLoS …, 2012 - journals.plos.org
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular
patterns to launch inflammatory responses leading to the activation of adaptive immunity …

Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export

D Gonzalez, MJ Grilló, MJ De Miguel, T Ali… - PLoS …, 2008 - journals.plos.org
Background The brucellae are facultative intracellular bacteria that cause brucellosis, one of
the major neglected zoonoses. In endemic areas, vaccination is the only effective way to …

Immune Response to Mucosal Brucella Infection

R López-Santiago, AB Sánchez-Argáez… - Frontiers in …, 2019 - frontiersin.org
Brucellosis is one of the most prevalent bacterial zoonosis of worldwide distribution. The
disease is caused by Brucella spp., facultative intracellular pathogens. Brucellosis in …

Brucella MucR acts as an H-NS-like protein to silence virulence genes and structure the nucleoid

IS Barton, Z Ren, CB Cribb, JE Pitzer, I Baglivo… - MBio, 2023 - Am Soc Microbiol
Histone-like nucleoid structuring (H-NS) and H-NS-like proteins serve as global gene
silencers and work with antagonistic transcriptional activators (counter-silencers) to properly …