During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …

Red blood cells (RBCs) units are the most requested transfusion product worldwide.
Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

In hemolytic diseases, such as sickle cell disease (SCD), intravascular hemolysis results in
the release of hemoglobin, heme, and heme-loaded membrane microvesicles in the …

Symbiotic partnerships with rhizobial bacteria enable legumes to grow without nitrogen
fertilizer because rhizobia convert atmospheric nitrogen gas into ammonia via nitrogenase …

Rationale: No medical intervention has been identified that decreases acute kidney injury
and improves renal outcome at 1 year after cardiac surgery. Objectives: To determine …

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative
stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free …

Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …

Vascular diseases are multifactorial, often requiring multiple challenges, or 'hits', for their
initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event …

Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …