Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It
remains an important and effective therapy in many forms of cancer today. Cisplatin …

Introduction Cisplatin, a platinum‐based antineoplastic agent, is the cornerstone for the
treatment of many malignancies. Nephrotoxicity is the primary dose‐limiting toxicity, and …

Over twenty years of intensive work toward improvement of cisplatin, and with hundreds of
platinum drugs tested, has resulted in the introduction of the widely used carboplatin and of …

Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we
clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter for …

Chemotherapy, surgery and radiotherapy continue to be the mainstay treatments of cancer.
Over 700 FDA-approved drugs have entered into clinical practice during the last 30 years …

Despite available prevention and treatment measures, such as hydration, diuresis,
magnesium supplementation, and amifostine, renal toxicity is still one of the major dose …

Background. Nephrotoxicity is the major limitation for the clinical use of cisplatin as an anti-
tumoural drug. Our aim was to investigate the protective effect of quercetin on cisplatin …

Importance Increased survival with immune checkpoint inhibitors has been reported for
patients with obesity vs a normal body mass index (BMI). However, the association of …

Cyclophosphamide (CPM), an alkylating agent is used as an immunosuppressant in
rheumatoid arthritis and in the treatment of several cancers as well. In this study, Ellagic acid …