Designing drugs and chemical probes with the dualsteric approach
J Zha, J He, C Wu, M Zhang, X Liu… - Chemical Society Reviews, 2023 - pubs.rsc.org
Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …
Strategies and progress in CXCR4-targeted anti-human immunodeficiency virus (HIV) therapeutic development
LSM Huang, EY Snyder… - Clinical Infectious …, 2021 - academic.oup.com
The acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has been a global public health challenge for several decades. The majority of …
virus (HIV), has been a global public health challenge for several decades. The majority of …
[HTML][HTML] Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism
SM Anbuhl, X Dervillez, S Neubacher, AI Schriek… - Biochemical …, 2024 - Elsevier
The chemokine receptor CXCR4 is involved in the development and migration of stem and
immune cells but is also implicated in tumor progression and metastasis for a variety of …
immune cells but is also implicated in tumor progression and metastasis for a variety of …
A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist
X Fang, Q Meng, H Zhang, X Fang, LS Huang… - European Journal of …, 2022 - Elsevier
Targeting the protein-protein interactions involving CXCR4, a member of chemokine
receptor family and G-protein-coupled receptor superfamily, has become an attractive …
receptor family and G-protein-coupled receptor superfamily, has become an attractive …
Discoveries and developments of CXCR4-targeted HIV-1 entry inhibitors
C Zhang, R Zhu, Q Cao, X Yang… - … Biology and Medicine, 2020 - journals.sagepub.com
The chemokine receptor CXCR4 is required for the entry of human immunodeficiency virus
type 1 (HIV-1) into target cells and its expression correlates with more profound …
type 1 (HIV-1) into target cells and its expression correlates with more profound …
Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists
X Fang, Q Meng, H Zhang, B Liang, S Zhu… - European Journal of …, 2020 - Elsevier
CXCR4, a well-studied coreceptor of human immunodeficiency virus type 1 (HIV-1) entry,
recognizes its cognate ligand SDF-1α (also named CXCL12) which plays many important …
recognizes its cognate ligand SDF-1α (also named CXCL12) which plays many important …
CXCR4 Recognition by L-and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120
R Zhu, X Sang, J Zhou, Q Meng, LSM Huang, Y Xu… - Viruses, 2023 - mdpi.com
Human immunodeficiency virus-1 (HIV-1) recognizes one of its principal coreceptors, CXC
chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 …
chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 …
HIV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop
R Zhu, Q Meng, H Zhang, G Zhang, LSM Huang… - European journal of …, 2022 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) recognizes one of its principal
coreceptors, the CXC chemokine receptor 4 (CXCR4) on the host cell via the third variable …
coreceptors, the CXC chemokine receptor 4 (CXCR4) on the host cell via the third variable …
Role of Interferon-Induced Protein With Tetratricopeptide Repeats 3 (IFIT3) in HIV-1 Associated Neurodegenerative Disorder and Alzheimer's Disease
RK Das - 2024 - search.proquest.com
The advent of cART has revolutionized the management of HIV-1 infection and saved the
lives of millions of people worldwide. Yet, HAND continues to be clinically relevant with …
lives of millions of people worldwide. Yet, HAND continues to be clinically relevant with …
[PDF][PDF] CXCR4 Recognition by L-and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120. Viruses 2023, 15, 1084
R Zhu, X Sang, J Zhou, Q Meng, LSM Huang… - Novel Antiviral …, 2023 - researchgate.net
Human immunodeficiency virus-1 (HIV-1) recognizes one of its principal coreceptors, CXC
chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 …
chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 …