From marine metabolites to the drugs of the future: Squalamine, trodusquemine, their steroid and triterpene analogues
O Kazakova, G Giniyatullina, D Babkov… - International journal of …, 2022 - mdpi.com
This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …
Recent progress in bile acid-based antimicrobials
C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) heavily burdened the entire world socially and economically. Despite a …
(SARS-CoV-2) heavily burdened the entire world socially and economically. Despite a …
The urgent need for novel antimicrobial agents and strategies to fight antibiotic resistance
MM D'Andrea, M Fraziano, MC Thaller, GM Rossolini - Antibiotics, 2019 - mdpi.com
Antibiotic resistance in bacterial pathogens has currently reached very high and alarming
levels. Indeed, according to a number of international bodies, this “antibiotic resistance …
levels. Indeed, according to a number of international bodies, this “antibiotic resistance …
Bactericidal activity of ceragenin in combination with ceftazidime, levofloxacin, co-trimoxazole, and colistin against the opportunistic pathogen Stenotrophomonas …
P Paprocka, A Mańkowska, K Skłodowski, G Król… - Pathogens, 2022 - mdpi.com
Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic
Gram-negative rod causing nosocomial infections predominantly in immunocompromised …
Gram-negative rod causing nosocomial infections predominantly in immunocompromised …
New β-lactam antibiotics and ceragenins–a study to assess their potential in treatment of infections caused by multidrug-resistant strains of Pseudomonas aeruginosa
P Paprocka, B Durnaś, A Mańkowska… - Infection and Drug …, 2021 - Taylor & Francis
Background The increasing number of infections caused by antibiotic resistant strains of
Pseudomonas aeruginosa posed a very serious challenge for clinical practice. This standing …
Pseudomonas aeruginosa posed a very serious challenge for clinical practice. This standing …
Incorporating Ceragenins into Coatings Protects Peripherally Inserted Central Catheter Lines against Pathogen Colonization for Multiple Weeks
A Zaugg, E Sherren, R Yi, T Larsen, B Dyck… - International journal of …, 2023 - mdpi.com
Healthcare-acquired infections and multi-drug resistance in pathogens pose a major crisis
for the healthcare industry. Novel antibiotics which are effective against resistant strains and …
for the healthcare industry. Novel antibiotics which are effective against resistant strains and …
NDM-1 carbapenemase-producing Enterobacteriaceae are highly susceptible to ceragenins CSA-13, CSA-44, and CSA-131
SJ Chmielewska, K Skłodowski, E Piktel… - Infection and drug …, 2020 - Taylor & Francis
Background and Purpose Treatment of infections caused by NDM-1 carbapenemase-
producing Enterobacteriaceae (CPE) represents one of the major challenges of modern …
producing Enterobacteriaceae (CPE) represents one of the major challenges of modern …
In vitro and in vivo activity of meropenem+avibactam against MBL-producing carbapenem-resistant Klebsiella pneumoniae
X Li, Z Chen, J Jiao, S Wang, Y Wang… - Expert Review of Anti …, 2023 - Taylor & Francis
Background Antibiotic resistance has become a public health problem to be solved
worldwide and metallo-β-lactamase (MBL)-producing bacteria make this problem even more …
worldwide and metallo-β-lactamase (MBL)-producing bacteria make this problem even more …
Characterization of endophytic Streptomyces griseorubens MPT42 and assessment of antimicrobial synergistic interactions of its extract and essential oil from host …
The present study aimed to evaluate the synergistic effects of the crude ethyl acetate extract
(CEAE) from endophytic actinomycete MPT42 and essential oil (EO) of the same host plant …
(CEAE) from endophytic actinomycete MPT42 and essential oil (EO) of the same host plant …