A resurgence of interest and investment in the field of gene therapy, driven in large part by
advances in viral vector technology, has recently culminated in United States Food and Drug …

Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective
therapy for ocular diseases, especially for the posterior segment, has been considered as a …

Nanocarriers, such as nanoparticles, have the capacity to deliver ocular drugs to specific
target sites and hold promise to revolutionize the therapy of many eye diseases. Results to …

Nanoscience and nanotechnology has caused important breakthroughs in different
therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led …

Since long before the first approval of gene therapy for retinal disease, ocular gene therapy
has captured the hopes of patients, clinicians, and scientists alike. Indeed, the retina …

Background: Ocular drug delivery is an extremely challenging area due to its restrictive
barrier functionalities. Objective: Drug transport via corneal/non-corneal routes involves …

Compared to intravitreal injection, subretinal injection has more direct effects on the
targeting cells in the subretinal space, which provides a new therapeutic method for …

Intravitreal administration of drugs has raised a large interest during the last two decades
improving the treatment of infectious diseases of the posterior segment of the eye or …

The eye is a highly specialized organ that is subject to a huge range of pathology. Both local
and systemic disease may affect different anatomical regions of the eye. The least invasive …

purpose. Gene therapy offers a promising alternative for the treatment of ocular diseases.
However, the implementation of this type of therapy is actually hampered by the lack of an …